TY - JOUR
T1 - 5-Methylcytosine immunohistochemistry for predicting cutaneous melanoma prognosis
AU - Meevassana, Jiraroch
AU - Varophas, Shananya
AU - Prabsattru, Piyawan
AU - Kamolratanakul, Supitcha
AU - Ruangritchankul, Komkrit
AU - Kitkumthorn, Nakarin
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - There is a correlation between DNA methylation and the diseased stage and poor survival. 5-methylcytosine (5-mC) is one of the epigenetic modifications of bases that researchers focus on. Staining with 5-mC immunohistochemistry was used to examine pathological samples taken from individuals diagnosed with cutaneous melanoma. Between Breslow levels 2 and 4, there was a significant difference in the H-score of 5-mC expression (p = 0.046). A significant reduction in 5-mC expression H-scores was seen in patients who were diagnosed with ulcers (p = 0.039). It was shown that patients with low 5-mC had a significantly worse overall survival rate (p = 0.027).
AB - There is a correlation between DNA methylation and the diseased stage and poor survival. 5-methylcytosine (5-mC) is one of the epigenetic modifications of bases that researchers focus on. Staining with 5-mC immunohistochemistry was used to examine pathological samples taken from individuals diagnosed with cutaneous melanoma. Between Breslow levels 2 and 4, there was a significant difference in the H-score of 5-mC expression (p = 0.046). A significant reduction in 5-mC expression H-scores was seen in patients who were diagnosed with ulcers (p = 0.039). It was shown that patients with low 5-mC had a significantly worse overall survival rate (p = 0.027).
UR - http://www.scopus.com/inward/record.url?scp=85188945064&partnerID=8YFLogxK
U2 - 10.1038/s41598-024-58011-z
DO - 10.1038/s41598-024-58011-z
M3 - Article
AN - SCOPUS:85188945064
SN - 2045-2322
VL - 14
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 7554
ER -
