A comparative study of the cytotoxic activities of three plants: Curcuma zedoaria, pinus maritima and curcuma xanthorrhiza on skin cancer A375 and HSC-5 cell lines

Sunisa Thaichinda, Thamthiwat Nararatwanchai, Salunya Tancharoen, Takuro Kanekura, Yuko Higashi

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Background-Nowadays much attention has been focus on the use of natural plant-derived therapies. The three kinds of Thai plants, Curcuma zedoaria (CZ), Pinus maritima (PM) and Curcuma xanthorrrhiza (CX) have been reported to have many biological and physiological properties and potential to be used as a medicine in many clinical heaths but its anti-cancer effect is still less well understood. Objective-To evaluate and compare the signaling cytotoxicity pathways of three kinds of Thai plants-CZ, PM, and CX through intracellular reactive oxygen species (ROS) in different dose on the skin cancer cell line A375 and HSC-5. Methods-We evaluated the cytotoxic activities of three plants-CZ, PM, and CX on human melanoma A375 cell line and squamous cell carcinoma HSC-5 cell line after their supplementation by detection of intracellular ROS using CM-H2DCFDA as the fluorescent probe. Results-We found that only PM significantly induced oxidative stress responses in term of ROS generation on both A375 cells and HSC-5 cell therefore, it was the most potentially cytotoxic effect within dose dependent. Conclusion-Bark extract from Pinus maritima has potentially cytotoxic and oxidative damage against both skin cancer cells by inducing ROS-mediated autosis.

Original languageEnglish
Title of host publication3rd International Conference on Digital Arts, Media and Technology, ICDAMT 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages301-304
Number of pages4
ISBN (Electronic)9781509052097
DOIs
Publication statusPublished - 8 Jun 2018
Event3rd International Conference on Digital Arts, Media and Technology, ICDAMT 2018 - Phayao, Thailand
Duration: 25 Feb 201828 Feb 2018

Publication series

Name3rd International Conference on Digital Arts, Media and Technology, ICDAMT 2018

Conference

Conference3rd International Conference on Digital Arts, Media and Technology, ICDAMT 2018
Country/TerritoryThailand
CityPhayao
Period25/02/1828/02/18

Keywords

  • Curcuma xanthorrrhiza
  • Curcuma zedoaria
  • Human Melanoma A375 cell line
  • Pinus maritima
  • Reactive oxygen species
  • Squamous cell carcinoma HSC-5 cell line

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