TY - JOUR
T1 - Biological Activities of Extracts and Secondary Metabolites from Millettia phuwuaensis
AU - Chaikrueang, Penpaka
AU - Pompimon, Wilart
AU - Udomputtimekakul, Phansuang
AU - Khamto, Nopawit
AU - Meepowpan, Puttinan
AU - Natetip, Pakpoom
AU - Khudngaongam, Nuntiya
AU - Wongjaren, Napakaon
AU - Khuntee, Duangsuda
AU - Michaidi, Khwanruethai
AU - Kongbun, Khanittha
AU - Chueakhamsao, Supaporn
AU - Issariyajongkol, Kanyawee
AU - Nuntasaen, Narong
AU - Suksen, Kanoknetr
AU - Chairoungdua, Arthit
AU - Limthongkul, Jitra
AU - Naparswad, Chanita
AU - Charoenphakinrattana, Nichapa
AU - Pikulthong, Suttiporn
N1 - Publisher Copyright:
© 2023 Chaikrueang et al.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - A study of the phytochemicals constituents of the stems of, Millettia phuwuaensis has led to the isolation of 7-methoxy-5/,6/-methylenedioxyisoflavone (1), and 12-deoxo-12α-hydroxyelliptone (2. Their structures were confirmed using NMR spectroscopy. Both extracts and the purified compounds were evaluated for their antibacterial, anti-HIV, and cancer activity. The antibacterial test results of the extracts and pure compound were found to be valuable, MIC is in the range of 12.5-200 mg/mL, in the range of 0.188-6 mg/mL, respectively. Mechanistic anti-HIV affect RT and MC99 found that ethyl acetate extract inhibited the very high level with IC50 with 75.93%. It was also found that all extracts were effective in inhibiting AIDs by mechanism MC99 at EC50 at 1.35 µM (TI>2.41). Further, the ethyl acetate extract showed marked cytotoxicity (ED50 = 17.58 µg/ml against the SH-SY5Y cancer cell line. Additionally, compound 1 also exhibited RT, moderately active with IC50 55.19 % inhibition. More than that, compounds 1 and 2 also exhibited MC99 at 50% (EC50) values of > 3.01 (TI >1.70) and 1.78 (TI >1.70), respectively.
AB - A study of the phytochemicals constituents of the stems of, Millettia phuwuaensis has led to the isolation of 7-methoxy-5/,6/-methylenedioxyisoflavone (1), and 12-deoxo-12α-hydroxyelliptone (2. Their structures were confirmed using NMR spectroscopy. Both extracts and the purified compounds were evaluated for their antibacterial, anti-HIV, and cancer activity. The antibacterial test results of the extracts and pure compound were found to be valuable, MIC is in the range of 12.5-200 mg/mL, in the range of 0.188-6 mg/mL, respectively. Mechanistic anti-HIV affect RT and MC99 found that ethyl acetate extract inhibited the very high level with IC50 with 75.93%. It was also found that all extracts were effective in inhibiting AIDs by mechanism MC99 at EC50 at 1.35 µM (TI>2.41). Further, the ethyl acetate extract showed marked cytotoxicity (ED50 = 17.58 µg/ml against the SH-SY5Y cancer cell line. Additionally, compound 1 also exhibited RT, moderately active with IC50 55.19 % inhibition. More than that, compounds 1 and 2 also exhibited MC99 at 50% (EC50) values of > 3.01 (TI >1.70) and 1.78 (TI >1.70), respectively.
KW - Biological activity
KW - Fabaceae
KW - Isoflavonoids
KW - Millettia phuwuaensis
KW - Rotenoids
UR - http://www.scopus.com/inward/record.url?scp=85148363639&partnerID=8YFLogxK
U2 - 10.26538/tjnpr/v7i1.17
DO - 10.26538/tjnpr/v7i1.17
M3 - Article
AN - SCOPUS:85148363639
SN - 2616-0684
VL - 7
SP - 2207
EP - 2212
JO - Tropical Journal of Natural Product Research
JF - Tropical Journal of Natural Product Research
IS - 1
ER -
