Boesenmaxane Diterpenoids from Boesenbergia maxwellii

The S. Moe; Suppisak Chaturonrutsamee; Samreang Bunteang; Chutima Kuhakarn; Samran Prabpai; Panida Surawatanawong; Arthit Chairoungdua; Kanoknetr Suksen; Radeekorn Akkarawongsapat; Jitra Limthongkul; Chanita Napaswad; Narong Nuntasaen; Vichai Reutrakul

doi:10.1021/acs.jnatprod.0c00629

Boesenmaxane Diterpenoids from Boesenbergia maxwellii

The S. Moe, Suppisak Chaturonrutsamee, Samreang Bunteang, Chutima Kuhakarn, Samran Prabpai, Panida Surawatanawong, Arthit Chairoungdua, Kanoknetr Suksen, Radeekorn Akkarawongsapat, Jitra Limthongkul, Chanita Napaswad, Narong Nuntasaen, Vichai Reutrakul

Research output: Contribution to journal › Article › peer-review

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Abstract

Three new diterpenoids, boesenmaxanes A-C (1-3), with an unprecedented core skeleton consisting of an unusual C-C bond between C-12 and an exo-cyclic methylene C-13, were isolated from the rhizome extracts of Boesenbergia maxwellii. The structures were elucidated by analysis of spectroscopic and X-ray diffraction data. Electronic circular dichroism spectra were used to determine the absolute configuration. All the isolates were evaluated for their cytotoxic effects, anti-HIV activity, and antimicrobial activity. Boesenmaxanes A and C (1 and 3) showed significant inhibitory activity in the syncytium reduction assay, with EC50 values of 55.2 and 27.5 μM, respectively.

Original language	English
Pages (from-to)	518-526
Number of pages	9
Journal	Journal of Natural Products
Volume	84
Issue number	2
DOIs	https://doi.org/10.1021/acs.jnatprod.0c00629
Publication status	Published - 26 Feb 2021
Externally published	Yes

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10.1021/acs.jnatprod.0c00629

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title = "Boesenmaxane Diterpenoids from Boesenbergia maxwellii",

abstract = "Three new diterpenoids, boesenmaxanes A-C (1-3), with an unprecedented core skeleton consisting of an unusual C-C bond between C-12 and an exo-cyclic methylene C-13, were isolated from the rhizome extracts of Boesenbergia maxwellii. The structures were elucidated by analysis of spectroscopic and X-ray diffraction data. Electronic circular dichroism spectra were used to determine the absolute configuration. All the isolates were evaluated for their cytotoxic effects, anti-HIV activity, and antimicrobial activity. Boesenmaxanes A and C (1 and 3) showed significant inhibitory activity in the syncytium reduction assay, with EC50 values of 55.2 and 27.5 μM, respectively.",

author = "Moe, {The S.} and Suppisak Chaturonrutsamee and Samreang Bunteang and Chutima Kuhakarn and Samran Prabpai and Panida Surawatanawong and Arthit Chairoungdua and Kanoknetr Suksen and Radeekorn Akkarawongsapat and Jitra Limthongkul and Chanita Napaswad and Narong Nuntasaen and Vichai Reutrakul",

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doi = "10.1021/acs.jnatprod.0c00629",

language = "English",

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TY - JOUR

T1 - Boesenmaxane Diterpenoids from Boesenbergia maxwellii

AU - Moe, The S.

AU - Chaturonrutsamee, Suppisak

AU - Bunteang, Samreang

AU - Kuhakarn, Chutima

AU - Prabpai, Samran

AU - Surawatanawong, Panida

AU - Chairoungdua, Arthit

AU - Suksen, Kanoknetr

AU - Akkarawongsapat, Radeekorn

AU - Limthongkul, Jitra

AU - Napaswad, Chanita

AU - Nuntasaen, Narong

AU - Reutrakul, Vichai

PY - 2021/2/26

Y1 - 2021/2/26

N2 - Three new diterpenoids, boesenmaxanes A-C (1-3), with an unprecedented core skeleton consisting of an unusual C-C bond between C-12 and an exo-cyclic methylene C-13, were isolated from the rhizome extracts of Boesenbergia maxwellii. The structures were elucidated by analysis of spectroscopic and X-ray diffraction data. Electronic circular dichroism spectra were used to determine the absolute configuration. All the isolates were evaluated for their cytotoxic effects, anti-HIV activity, and antimicrobial activity. Boesenmaxanes A and C (1 and 3) showed significant inhibitory activity in the syncytium reduction assay, with EC50 values of 55.2 and 27.5 μM, respectively.

AB - Three new diterpenoids, boesenmaxanes A-C (1-3), with an unprecedented core skeleton consisting of an unusual C-C bond between C-12 and an exo-cyclic methylene C-13, were isolated from the rhizome extracts of Boesenbergia maxwellii. The structures were elucidated by analysis of spectroscopic and X-ray diffraction data. Electronic circular dichroism spectra were used to determine the absolute configuration. All the isolates were evaluated for their cytotoxic effects, anti-HIV activity, and antimicrobial activity. Boesenmaxanes A and C (1 and 3) showed significant inhibitory activity in the syncytium reduction assay, with EC50 values of 55.2 and 27.5 μM, respectively.

UR - http://www.scopus.com/inward/record.url?scp=85099089779&partnerID=8YFLogxK

U2 - 10.1021/acs.jnatprod.0c00629

DO - 10.1021/acs.jnatprod.0c00629

M3 - Article

C2 - 33372792

AN - SCOPUS:85099089779

SN - 0163-3864

VL - 84

SP - 518

EP - 526

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Boesenmaxane Diterpenoids from Boesenbergia maxwellii

Abstract

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