TY - JOUR
T1 - Comparison of community-onset Staphylococcus argenteus and Staphylococcus aureus sepsis in Thailand
T2 - A prospective multicentre observational study
AU - Chantratita, N.
AU - Wikraiphat, C.
AU - Tandhavanant, S.
AU - Wongsuvan, G.
AU - Ariyaprasert, P.
AU - Suntornsut, P.
AU - Thaipadungpanit, J.
AU - Teerawattanasook, N.
AU - Jutrakul, Y.
AU - Srisurat, N.
AU - Chaimanee, P.
AU - Anukunananchai, J.
AU - Phiphitaporn, S.
AU - Srisamang, P.
AU - Chetchotisakd, P.
AU - West, T. E.
AU - Peacock, S. J.
N1 - Publisher Copyright:
© 2016 The Authors.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Staphylococcus argenteus is a globally distributed cause of human infection, but diagnostic laboratories misidentify this as Staphylococcus aureus. We determined whether there is clinical utility in distinguishing between the two. A prospective cohort study of community-onset invasive staphylococcal sepsis was conducted in adults at four hospitals in northeast Thailand between 2010 and 2013. Of 311 patients analysed, 58 (19%) were infected with S. argenteus and 253 (81%) with S. aureus. Most S. argenteus (54/58) were multilocus sequence type 2250. Infection with S. argenteus was more common in males, but rates of bacteraemia and drainage procedures were similar in the two groups. S. argenteus precipitated significantly less respiratory failure than S. aureus (5.2% versus 20.2%, adjusted OR 0.21, 95% CI 0.06-0.74, p 0.015), with a similar but non-significant trend for shock (6.9% versus 12.3%, adjusted OR 0.46, 95% CI 0.15-1.44, p 0.18). This did not translate into a difference in death at 28 days (6.9% versus 8.7%, adjusted OR 0.80, 95% CI 0.24-2.65, p 0.72). S. argenteus was more susceptible to antimicrobial drugs compared with S. aureus, and contained fewer toxin genes although pvl was detected in 16% (9/58). We conclude that clinical differences exist in association with sepsis due to S. argenteus versus S. aureus.
AB - Staphylococcus argenteus is a globally distributed cause of human infection, but diagnostic laboratories misidentify this as Staphylococcus aureus. We determined whether there is clinical utility in distinguishing between the two. A prospective cohort study of community-onset invasive staphylococcal sepsis was conducted in adults at four hospitals in northeast Thailand between 2010 and 2013. Of 311 patients analysed, 58 (19%) were infected with S. argenteus and 253 (81%) with S. aureus. Most S. argenteus (54/58) were multilocus sequence type 2250. Infection with S. argenteus was more common in males, but rates of bacteraemia and drainage procedures were similar in the two groups. S. argenteus precipitated significantly less respiratory failure than S. aureus (5.2% versus 20.2%, adjusted OR 0.21, 95% CI 0.06-0.74, p 0.015), with a similar but non-significant trend for shock (6.9% versus 12.3%, adjusted OR 0.46, 95% CI 0.15-1.44, p 0.18). This did not translate into a difference in death at 28 days (6.9% versus 8.7%, adjusted OR 0.80, 95% CI 0.24-2.65, p 0.72). S. argenteus was more susceptible to antimicrobial drugs compared with S. aureus, and contained fewer toxin genes although pvl was detected in 16% (9/58). We conclude that clinical differences exist in association with sepsis due to S. argenteus versus S. aureus.
KW - Prevalence
KW - Sepsis
KW - Staphylococcus argenteus
KW - Staphylococcus aureus
KW - Thailand
UR - http://www.scopus.com/inward/record.url?scp=84961124211&partnerID=8YFLogxK
U2 - 10.1016/j.cmi.2016.01.008
DO - 10.1016/j.cmi.2016.01.008
M3 - Article
C2 - 26806258
AN - SCOPUS:84961124211
SN - 1198-743X
VL - 22
SP - 458.e11-458.e19
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - 5
ER -