TY - JOUR
T1 - Human Leukocyte Antigen (HLA) System
T2 - Genetics and Association with Bacterial and Viral Infections
AU - Medhasi, Sadeep
AU - Chantratita, Narisara
N1 - Publisher Copyright:
© 2022 Sadeep Medhasi and Narisara Chantratita.
PY - 2022
Y1 - 2022
N2 - The human leukocyte antigen (HLA) system is one of the most crucial host factors influencing disease progression in bacterial and viral infections. This review provides the basic concepts of the structure and function of HLA molecules in humans. Here, we highlight the main findings on the associations between HLA class I and class II alleles and susceptibility to important infectious diseases such as tuberculosis, leprosy, melioidosis, Staphylococcus aureus infection, human immunodeficiency virus infection, coronavirus disease 2019, hepatitis B, and hepatitis C in populations worldwide. Finally, we discuss challenges in HLA typing to predict disease outcomes in clinical implementation. Evaluation of the impact of HLA variants on the outcome of bacterial and viral infections would improve the understanding of pathogenesis and identify those at risk from infectious diseases in distinct populations and may improve the individual treatment.
AB - The human leukocyte antigen (HLA) system is one of the most crucial host factors influencing disease progression in bacterial and viral infections. This review provides the basic concepts of the structure and function of HLA molecules in humans. Here, we highlight the main findings on the associations between HLA class I and class II alleles and susceptibility to important infectious diseases such as tuberculosis, leprosy, melioidosis, Staphylococcus aureus infection, human immunodeficiency virus infection, coronavirus disease 2019, hepatitis B, and hepatitis C in populations worldwide. Finally, we discuss challenges in HLA typing to predict disease outcomes in clinical implementation. Evaluation of the impact of HLA variants on the outcome of bacterial and viral infections would improve the understanding of pathogenesis and identify those at risk from infectious diseases in distinct populations and may improve the individual treatment.
UR - http://www.scopus.com/inward/record.url?scp=85131348118&partnerID=8YFLogxK
U2 - 10.1155/2022/9710376
DO - 10.1155/2022/9710376
M3 - Review article
C2 - 35664353
AN - SCOPUS:85131348118
SN - 2314-8861
VL - 2022
JO - Journal of Immunology Research
JF - Journal of Immunology Research
M1 - 9710376
ER -