Immunopathogenesis of Dengue Virus-Induced Redundant Cell Death: Apoptosis and Pyroptosis

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22 Citations (Scopus)

Abstract

Dengue virus infection is a self-limited condition, which is of particular importance in tropical and subtropical regions and for which no specific treatment or effective vaccine is available. There are several hypotheses explaining dengue pathogenesis. These usually refer to host immune responses, including antibody-dependent enhancement, cytokine expression, and dengue virus particles including NS1 protein, which lead to cell death by both apoptosis and pyroptosis. A clear understanding of the pathogenesis should facilitate the development of vaccines and therapies. This review focuses on the immunopathogenesis in relation to clinical manifestations and patterns of cell death, focusing on the pathogenesis of severe dengue.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalViral Immunology
Volume30
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • apoptosis
  • dengue pathogenesis
  • pyroptosis

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