Lanostane derivatives from the leaves and twigs of Garcinia wallichii

Sasitorn Jaitheerapapkul; Chutima Kuhakarn; Sakchai Hongthong; Natthinee Anantachoke; Sariyarach Thanasansurapong; Arthit Chairoungdua; Kanoknetr Suksen; Narong Nuntasaen; Vichai Reutrakul

doi:10.1016/j.phytol.2020.05.005

Lanostane derivatives from the leaves and twigs of Garcinia wallichii

Sasitorn Jaitheerapapkul, Chutima Kuhakarn, Sakchai Hongthong, Natthinee Anantachoke, Sariyarach Thanasansurapong, Arthit Chairoungdua, Kanoknetr Suksen, Narong Nuntasaen, Vichai Reutrakul

Department of Pharmacognosy

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Bioassay-guided purification of the n-hexane and ethyl acetate extracts of the leaves and twigs of Garcinia wallichii led to the isolation of four previously undescribed lanostane triterpenes, wallichinanes F–I (1–4), together with four known compounds, wallichinane A (5), wallichinane B (6), friedelin (7), and lupeol (8). All structures were determined by means of spectroscopic techniques as well as comparison with literature data. Some isolated compounds were evaluated for cytotoxicity against a panel of cultured mammalian cancer cell lines. Wallichinanes G and H displayed weak cytotoxicity, whereas wallichinanes A, B, and F were found to be inactive in all the tested cell lines.

Original language	English
Pages (from-to)	101-106
Number of pages	6
Journal	Phytochemistry Letters
Volume	38
DOIs	https://doi.org/10.1016/j.phytol.2020.05.005
Publication status	Published - Aug 2020

Keywords

Cytotoxicity
Garcinia wallichii
Guttiferae
Lanostanes
Triterpenes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2020.05.005

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title = "Lanostane derivatives from the leaves and twigs of Garcinia wallichii",

abstract = "Bioassay-guided purification of the n-hexane and ethyl acetate extracts of the leaves and twigs of Garcinia wallichii led to the isolation of four previously undescribed lanostane triterpenes, wallichinanes F–I (1–4), together with four known compounds, wallichinane A (5), wallichinane B (6), friedelin (7), and lupeol (8). All structures were determined by means of spectroscopic techniques as well as comparison with literature data. Some isolated compounds were evaluated for cytotoxicity against a panel of cultured mammalian cancer cell lines. Wallichinanes G and H displayed weak cytotoxicity, whereas wallichinanes A, B, and F were found to be inactive in all the tested cell lines.",

keywords = "Cytotoxicity, Garcinia wallichii, Guttiferae, Lanostanes, Triterpenes",

author = "Sasitorn Jaitheerapapkul and Chutima Kuhakarn and Sakchai Hongthong and Natthinee Anantachoke and Sariyarach Thanasansurapong and Arthit Chairoungdua and Kanoknetr Suksen and Narong Nuntasaen and Vichai Reutrakul",

note = "Publisher Copyright: {\textcopyright} 2020 Phytochemical Society of Europe",

year = "2020",

month = aug,

doi = "10.1016/j.phytol.2020.05.005",

language = "English",

volume = "38",

pages = "101--106",

journal = "Phytochemistry Letters",

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T1 - Lanostane derivatives from the leaves and twigs of Garcinia wallichii

AU - Jaitheerapapkul, Sasitorn

AU - Kuhakarn, Chutima

AU - Hongthong, Sakchai

AU - Anantachoke, Natthinee

AU - Thanasansurapong, Sariyarach

AU - Chairoungdua, Arthit

AU - Suksen, Kanoknetr

AU - Nuntasaen, Narong

AU - Reutrakul, Vichai

PY - 2020/8

Y1 - 2020/8

N2 - Bioassay-guided purification of the n-hexane and ethyl acetate extracts of the leaves and twigs of Garcinia wallichii led to the isolation of four previously undescribed lanostane triterpenes, wallichinanes F–I (1–4), together with four known compounds, wallichinane A (5), wallichinane B (6), friedelin (7), and lupeol (8). All structures were determined by means of spectroscopic techniques as well as comparison with literature data. Some isolated compounds were evaluated for cytotoxicity against a panel of cultured mammalian cancer cell lines. Wallichinanes G and H displayed weak cytotoxicity, whereas wallichinanes A, B, and F were found to be inactive in all the tested cell lines.

AB - Bioassay-guided purification of the n-hexane and ethyl acetate extracts of the leaves and twigs of Garcinia wallichii led to the isolation of four previously undescribed lanostane triterpenes, wallichinanes F–I (1–4), together with four known compounds, wallichinane A (5), wallichinane B (6), friedelin (7), and lupeol (8). All structures were determined by means of spectroscopic techniques as well as comparison with literature data. Some isolated compounds were evaluated for cytotoxicity against a panel of cultured mammalian cancer cell lines. Wallichinanes G and H displayed weak cytotoxicity, whereas wallichinanes A, B, and F were found to be inactive in all the tested cell lines.

KW - Cytotoxicity

KW - Garcinia wallichii

KW - Guttiferae

KW - Lanostanes

KW - Triterpenes

UR - http://www.scopus.com/inward/record.url?scp=85086605969&partnerID=8YFLogxK

U2 - 10.1016/j.phytol.2020.05.005

DO - 10.1016/j.phytol.2020.05.005

M3 - Article

AN - SCOPUS:85086605969

SN - 1874-3900

VL - 38

SP - 101

EP - 106

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Lanostane derivatives from the leaves and twigs of Garcinia wallichii

Abstract

Keywords

UN SDGs

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