Mallotumides A−C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus

Natthapat Sawektreeratana; Chongkon Krachangchaeng; Prapadsorn Pittayanurak; Nolan M. Betterley; Arthit Chairoungdua; Anongnat Wongpan; Wittaya Panvongsa; Pattarapapa Janthakit; Phattananawee Nalaoh; Vinich Promarak; Narong Nuntasaen; Vichai Reutrakul; Chutima Kuhakarn; Sakchai Hongthong

doi:10.1021/acs.orglett.3c02641

Mallotumides A−C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus

Natthapat Sawektreeratana, Chongkon Krachangchaeng, Prapadsorn Pittayanurak, Nolan M. Betterley, Arthit Chairoungdua, Anongnat Wongpan, Wittaya Panvongsa, Pattarapapa Janthakit, Phattananawee Nalaoh, Vinich Promarak, Narong Nuntasaen, Vichai Reutrakul, Chutima Kuhakarn, Sakchai Hongthong

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The structures of potent cytotoxic cycloheptapeptides, mallotumides A−C (1−3, respectively) isolated from the roots of Mallotus spodocarpus Airy Shaw, were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by single-crystal X-ray crystallographic data. All three cycloheptapeptides exhibited potent cytotoxicity against various cancer cell lines with IC₅₀ values ranging from 0.60 to 4.02 nM.

Original language	English
Pages (from-to)	8183-8187
Number of pages	5
Journal	Organic Letters
Volume	25
Issue number	46
DOIs	https://doi.org/10.1021/acs.orglett.3c02641
Publication status	Published - 24 Nov 2023

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Sawektreeratana, N., Krachangchaeng, C., Pittayanurak, P., Betterley, N. M., Chairoungdua, A., Wongpan, A., Panvongsa, W., Janthakit, P., Nalaoh, P., Promarak, V., Nuntasaen, N., Reutrakul, V., Kuhakarn, C., & Hongthong, S. (2023). Mallotumides A−C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus. Organic Letters, 25(46), 8183-8187. https://doi.org/10.1021/acs.orglett.3c02641

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title = "Mallotumides A−C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus",

abstract = "The structures of potent cytotoxic cycloheptapeptides, mallotumides A−C (1−3, respectively) isolated from the roots of Mallotus spodocarpus Airy Shaw, were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by single-crystal X-ray crystallographic data. All three cycloheptapeptides exhibited potent cytotoxicity against various cancer cell lines with IC50 values ranging from 0.60 to 4.02 nM.",

author = "Natthapat Sawektreeratana and Chongkon Krachangchaeng and Prapadsorn Pittayanurak and Betterley, {Nolan M.} and Arthit Chairoungdua and Anongnat Wongpan and Wittaya Panvongsa and Pattarapapa Janthakit and Phattananawee Nalaoh and Vinich Promarak and Narong Nuntasaen and Vichai Reutrakul and Chutima Kuhakarn and Sakchai Hongthong",

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doi = "10.1021/acs.orglett.3c02641",

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Sawektreeratana, N, Krachangchaeng, C, Pittayanurak, P, Betterley, NM, Chairoungdua, A, Wongpan, A, Panvongsa, W, Janthakit, P, Nalaoh, P, Promarak, V, Nuntasaen, N, Reutrakul, V, Kuhakarn, C & Hongthong, S 2023, 'Mallotumides A−C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus', Organic Letters, vol. 25, no. 46, pp. 8183-8187. https://doi.org/10.1021/acs.orglett.3c02641

TY - JOUR

T1 - Mallotumides A−C

T2 - Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus

AU - Sawektreeratana, Natthapat

AU - Krachangchaeng, Chongkon

AU - Pittayanurak, Prapadsorn

AU - Betterley, Nolan M.

AU - Chairoungdua, Arthit

AU - Wongpan, Anongnat

AU - Panvongsa, Wittaya

AU - Janthakit, Pattarapapa

AU - Nalaoh, Phattananawee

AU - Promarak, Vinich

AU - Nuntasaen, Narong

AU - Reutrakul, Vichai

AU - Kuhakarn, Chutima

AU - Hongthong, Sakchai

PY - 2023/11/24

Y1 - 2023/11/24

N2 - The structures of potent cytotoxic cycloheptapeptides, mallotumides A−C (1−3, respectively) isolated from the roots of Mallotus spodocarpus Airy Shaw, were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by single-crystal X-ray crystallographic data. All three cycloheptapeptides exhibited potent cytotoxicity against various cancer cell lines with IC50 values ranging from 0.60 to 4.02 nM.

AB - The structures of potent cytotoxic cycloheptapeptides, mallotumides A−C (1−3, respectively) isolated from the roots of Mallotus spodocarpus Airy Shaw, were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by single-crystal X-ray crystallographic data. All three cycloheptapeptides exhibited potent cytotoxicity against various cancer cell lines with IC50 values ranging from 0.60 to 4.02 nM.

UR - http://www.scopus.com/inward/record.url?scp=85178495204&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.3c02641

DO - 10.1021/acs.orglett.3c02641

M3 - Article

C2 - 37902783

AN - SCOPUS:85178495204

SN - 1523-7060

VL - 25

SP - 8183

EP - 8187

JO - Organic Letters

JF - Organic Letters

IS - 46

ER -

Mallotumides A−C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus

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