Metal ion release and cytotoxicity of titanium orthodontic miniscrews

Katha Kosayadiloka, Nathaphon Tangjit, Suwannee Luppanapornlarp, Peerapong Santiwong

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

The aim of this study was to investigate the metal ion release and cytotoxicity of MU orthodontic miniscrews as well as two other brands of orthodontic miniscrews over time. Twenty-four orthodontic miniscrews were tested, divided into three groups of eight. Each sample extraction was performed following the ISO 10993-12:2012 method. Solutions were collected after 1, 7, and 30 days (T1, T2, and T3). The supernatants extracted from these three groups were added and exposed to mouse L929 fibroblastic cell line using an MTT cytotoxicity test. They were also tested for ion release by inductively coupled plasma-mass spectrometry (ICP-MS). Element analysis by energy-dispersive X-ray spectroscopy (EDS) was used to analyze the surfaces of the miniscrews. The quantification of three elements, namely, titanium (Ti), aluminum (Al), and vanadium (V) were assessed. The results indicated that there were no statistical differences between the self-made orthodontic miniscrews and those from two commercial groups (p<0.05). Throughout the testing period, the quantity of ions increased from T1 to T3. After 24 h, vanadium was the first to appear on the surface in small quantities in other two commercial groups. The self-made orthodontic miniscrews exhibited no toxic effects on living cells.

Original languageEnglish
Title of host publicationInnovative Materials
Subtitle of host publicationEngineering and Applications II
EditorsJung Kyu Ahn
PublisherTrans Tech Publications Ltd
Pages141-147
Number of pages7
ISBN (Print)9783038357834
DOIs
Publication statusPublished - 2017
EventInternational Conference on Material Engineering and Application, ICMEA 2016 - Tin Shui Wai, Hong Kong
Duration: 19 Aug 201621 Aug 2016

Publication series

NameKey Engineering Materials
Volume730 KEM
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Conference

ConferenceInternational Conference on Material Engineering and Application, ICMEA 2016
Country/TerritoryHong Kong
CityTin Shui Wai
Period19/08/1621/08/16

Keywords

  • Biocompatibility
  • Cytotoxicity
  • Ion release
  • Miniscrews

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