TY - GEN
T1 - Nano-Coating of Metronidazole on Dental Implants for Antibacterial Application
AU - Nasongkla, Norased
AU - Tanesanukul, Chayanan
AU - Nilyok, Sirawit
AU - Wongsuwan, Nattarat
AU - Tancharoen, Salunya
AU - Nilanont, Supassara
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2018/7/2
Y1 - 2018/7/2
N2 - Nano-coating on dental implants for antibacterial applications was studied for the inhibition of Porphyromonas gingivalis biofilm formation. In this work, metronidazole, an antibacterial agent, was loaded in niosomes and coated on dental implants using layer-by-layer dip coating technique with poly(lactic acid) (PLA). Drug loaded niosomes was fabricated via thin film hydration method. The niosomes was coated by varying the dipping cycle. The dental implants were coated for 90 cycles and were characterized further to determine drug loading content, release profile and inhibition zone. In detail, average drug loading content was 22.85 ± 1.56 μg. Antibacterial study showed that Metronidazole release could inhibit bacteria. Therefore, the result suggested that the layer-by-layer dip coating on dental implants for antibacterial application could be potentially elevated by using niosomes.
AB - Nano-coating on dental implants for antibacterial applications was studied for the inhibition of Porphyromonas gingivalis biofilm formation. In this work, metronidazole, an antibacterial agent, was loaded in niosomes and coated on dental implants using layer-by-layer dip coating technique with poly(lactic acid) (PLA). Drug loaded niosomes was fabricated via thin film hydration method. The niosomes was coated by varying the dipping cycle. The dental implants were coated for 90 cycles and were characterized further to determine drug loading content, release profile and inhibition zone. In detail, average drug loading content was 22.85 ± 1.56 μg. Antibacterial study showed that Metronidazole release could inhibit bacteria. Therefore, the result suggested that the layer-by-layer dip coating on dental implants for antibacterial application could be potentially elevated by using niosomes.
UR - http://www.scopus.com/inward/record.url?scp=85063065879&partnerID=8YFLogxK
U2 - 10.1109/NANOMED.2018.8641568
DO - 10.1109/NANOMED.2018.8641568
M3 - Conference contribution
AN - SCOPUS:85063065879
T3 - IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
SP - 59
EP - 62
BT - Proceedings of the 12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018
PB - IEEE Computer Society
T2 - 12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018
Y2 - 2 December 2018 through 5 December 2018
ER -