Nano-Coating of Metronidazole on Dental Implants for Antibacterial Application

Norased Nasongkla, Chayanan Tanesanukul, Sirawit Nilyok, Nattarat Wongsuwan, Salunya Tancharoen, Supassara Nilanont

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

7 Citations (Scopus)

Abstract

Nano-coating on dental implants for antibacterial applications was studied for the inhibition of Porphyromonas gingivalis biofilm formation. In this work, metronidazole, an antibacterial agent, was loaded in niosomes and coated on dental implants using layer-by-layer dip coating technique with poly(lactic acid) (PLA). Drug loaded niosomes was fabricated via thin film hydration method. The niosomes was coated by varying the dipping cycle. The dental implants were coated for 90 cycles and were characterized further to determine drug loading content, release profile and inhibition zone. In detail, average drug loading content was 22.85 ± 1.56 μg. Antibacterial study showed that Metronidazole release could inhibit bacteria. Therefore, the result suggested that the layer-by-layer dip coating on dental implants for antibacterial application could be potentially elevated by using niosomes.

Original languageEnglish
Title of host publicationProceedings of the 12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018
PublisherIEEE Computer Society
Pages59-62
Number of pages4
ISBN (Electronic)9781538675786
DOIs
Publication statusPublished - 2 Jul 2018
Event12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018 - Waikiki Beach, United States
Duration: 2 Dec 20185 Dec 2018

Publication series

NameIEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
Volume2018-December
ISSN (Print)2159-6964
ISSN (Electronic)2159-6972

Conference

Conference12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018
Country/TerritoryUnited States
CityWaikiki Beach
Period2/12/185/12/18

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