New ansamycins from the deep-sea-derived bacterium ochrobactrum sp. OUCMDZ-2164

Yaqin Fan; Cong Wang; Liping Wang; Arthit Chairoungdua; Pawinee Piyachaturawat; Peng Fu; Weiming Zhu

doi:10.3390/md16080282

New ansamycins from the deep-sea-derived bacterium ochrobactrum sp. OUCMDZ-2164

Yaqin Fan, Cong Wang, Liping Wang, Arthit Chairoungdua, Pawinee Piyachaturawat, Peng Fu, Weiming Zhu

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey’s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC₅₀ values of 15 and 23 µM, respectively.

Original language	English
Article number	282
Journal	Marine Drugs
Volume	16
Issue number	8
DOIs	https://doi.org/10.3390/md16080282
Publication status	Published - 15 Aug 2018
Externally published	Yes

Keywords

Ansamycins
Cytotoxic activity
Deep-sea-derived bacterium
Ochrobactrum sp.
Trienomycins

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10.3390/md16080282

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title = "New ansamycins from the deep-sea-derived bacterium ochrobactrum sp. OUCMDZ-2164",

abstract = "Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey{\textquoteright}s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC50 values of 15 and 23 µM, respectively.",

keywords = "Ansamycins, Cytotoxic activity, Deep-sea-derived bacterium, Ochrobactrum sp., Trienomycins",

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AU - Fan, Yaqin

AU - Wang, Cong

AU - Wang, Liping

AU - Chairoungdua, Arthit

AU - Piyachaturawat, Pawinee

AU - Fu, Peng

AU - Zhu, Weiming

PY - 2018/8/15

Y1 - 2018/8/15

N2 - Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey’s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC50 values of 15 and 23 µM, respectively.

AB - Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey’s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC50 values of 15 and 23 µM, respectively.

KW - Ansamycins

KW - Cytotoxic activity

KW - Deep-sea-derived bacterium

KW - Ochrobactrum sp.

KW - Trienomycins

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DO - 10.3390/md16080282

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AN - SCOPUS:85053718332

SN - 1660-3397

VL - 16

JO - Marine Drugs

JF - Marine Drugs

IS - 8

M1 - 282

ER -

New ansamycins from the deep-sea-derived bacterium ochrobactrum sp. OUCMDZ-2164

Abstract

Keywords

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