TY - JOUR
T1 - Ophiobolins from the Mangrove Fungus Aspergillus ustus
AU - Zhu, Tonghan
AU - Lu, Zhenyu
AU - Fan, Jie
AU - Wang, Liping
AU - Zhu, Guoliang
AU - Wang, Yi
AU - Li, Xia
AU - Hong, Kui
AU - Piyachaturawat, Pawinee
AU - Chairoungdua, Arthit
AU - Zhu, Weiming
N1 - Publisher Copyright:
© 2017 The American Chemical Society and American Society of Pharmacognosy.
PY - 2018/1/26
Y1 - 2018/1/26
N2 - Seven new ophiobolins (1-5, 12, and 14) along with the 11 known analogues (6-11, 13, 15-18) were isolated from the ethyl acetate extracts of the liquid and solid cultures of the mangrove fungus Aspergillus ustus 094102. The structures including the absolute configurations of the seven new compounds were elucidated by spectroscopic analysis, chemical methods, and quantum ECD calculations. Compounds 4-8 and 11-15 showed cytotoxicities against the G3K, MCF-7, MD-MBA-231, MCF/Adr, A549, and HL-60 human cancer cell lines with the IC 50 values ranging from 0.6 to 9.5 μM.
AB - Seven new ophiobolins (1-5, 12, and 14) along with the 11 known analogues (6-11, 13, 15-18) were isolated from the ethyl acetate extracts of the liquid and solid cultures of the mangrove fungus Aspergillus ustus 094102. The structures including the absolute configurations of the seven new compounds were elucidated by spectroscopic analysis, chemical methods, and quantum ECD calculations. Compounds 4-8 and 11-15 showed cytotoxicities against the G3K, MCF-7, MD-MBA-231, MCF/Adr, A549, and HL-60 human cancer cell lines with the IC 50 values ranging from 0.6 to 9.5 μM.
UR - http://www.scopus.com/inward/record.url?scp=85041213491&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.7b00335
DO - 10.1021/acs.jnatprod.7b00335
M3 - Article
C2 - 29286660
AN - SCOPUS:85041213491
SN - 0163-3864
VL - 81
SP - 2
EP - 9
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 1
ER -
