Poly(ϵ-Caprolactone) Nanospheres Coated on Dental Implants by Integrated Layer-by-Layer Coating Technique

Napossorn Patiyananuwat, Thanaphat Chartpitak, Salunya Tancharoen, Norased Nasongkla

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Dental implant infections are a leading cause of implant failure, causing inflammation and bone loss. To combat such infections, a potential solution is the application of a nano-coating technique that utilizes nanotechnology and a drug delivery system to coat the implant surface. This study aimed to coat dental implants with poly(ϵ-caprolactone) nanospheres (PCL-NPs) loaded with minocycline (MC), an antibacterial agent, using the Layer-by-Layer (LbL) coating technique involving dipping and spraying. The dental implants were coated for 30, 60, 90, and 120 cycles, respectively. The MC/PCL- NPs achieved drug-loading contents of 0.16 ± 0.03, 3.03 ± 0.99, 5.87 ± 0.69, and 6.48 ± 1.68 mg, respectively. The antibacterial study revealed that the release profile of minocycline from the coated dental implants effectively inhibited bacteria growth for a duration of three days.

Original languageEnglish
Title of host publication2023 IEEE 23rd International Conference on Nanotechnology, NANO 2023
PublisherIEEE Computer Society
Pages484-489
Number of pages6
ISBN (Electronic)9798350333466
DOIs
Publication statusPublished - 2023
Event23rd IEEE International Conference on Nanotechnology, NANO 2023 - Jeju City, Korea, Republic of
Duration: 2 Jul 20235 Jul 2023

Publication series

NameProceedings of the IEEE Conference on Nanotechnology
Volume2023-July
ISSN (Print)1944-9399
ISSN (Electronic)1944-9380

Conference

Conference23rd IEEE International Conference on Nanotechnology, NANO 2023
Country/TerritoryKorea, Republic of
CityJeju City
Period2/07/235/07/23

Keywords

  • Dental implant
  • drug delivery system
  • minocycline
  • nano-coating
  • nanospheres
  • poly(ϵ-caprolactone)

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