TY - GEN
T1 - Poly(ϵ-Caprolactone) Nanospheres Coated on Dental Implants by Integrated Layer-by-Layer Coating Technique
AU - Patiyananuwat, Napossorn
AU - Chartpitak, Thanaphat
AU - Tancharoen, Salunya
AU - Nasongkla, Norased
N1 - Publisher Copyright:
© 2023 IEEE.
PY - 2023
Y1 - 2023
N2 - Dental implant infections are a leading cause of implant failure, causing inflammation and bone loss. To combat such infections, a potential solution is the application of a nano-coating technique that utilizes nanotechnology and a drug delivery system to coat the implant surface. This study aimed to coat dental implants with poly(ϵ-caprolactone) nanospheres (PCL-NPs) loaded with minocycline (MC), an antibacterial agent, using the Layer-by-Layer (LbL) coating technique involving dipping and spraying. The dental implants were coated for 30, 60, 90, and 120 cycles, respectively. The MC/PCL- NPs achieved drug-loading contents of 0.16 ± 0.03, 3.03 ± 0.99, 5.87 ± 0.69, and 6.48 ± 1.68 mg, respectively. The antibacterial study revealed that the release profile of minocycline from the coated dental implants effectively inhibited bacteria growth for a duration of three days.
AB - Dental implant infections are a leading cause of implant failure, causing inflammation and bone loss. To combat such infections, a potential solution is the application of a nano-coating technique that utilizes nanotechnology and a drug delivery system to coat the implant surface. This study aimed to coat dental implants with poly(ϵ-caprolactone) nanospheres (PCL-NPs) loaded with minocycline (MC), an antibacterial agent, using the Layer-by-Layer (LbL) coating technique involving dipping and spraying. The dental implants were coated for 30, 60, 90, and 120 cycles, respectively. The MC/PCL- NPs achieved drug-loading contents of 0.16 ± 0.03, 3.03 ± 0.99, 5.87 ± 0.69, and 6.48 ± 1.68 mg, respectively. The antibacterial study revealed that the release profile of minocycline from the coated dental implants effectively inhibited bacteria growth for a duration of three days.
KW - Dental implant
KW - drug delivery system
KW - minocycline
KW - nano-coating
KW - nanospheres
KW - poly(ϵ-caprolactone)
UR - http://www.scopus.com/inward/record.url?scp=85173589680&partnerID=8YFLogxK
U2 - 10.1109/NANO58406.2023.10231250
DO - 10.1109/NANO58406.2023.10231250
M3 - Conference contribution
AN - SCOPUS:85173589680
T3 - Proceedings of the IEEE Conference on Nanotechnology
SP - 484
EP - 489
BT - 2023 IEEE 23rd International Conference on Nanotechnology, NANO 2023
PB - IEEE Computer Society
T2 - 23rd IEEE International Conference on Nanotechnology, NANO 2023
Y2 - 2 July 2023 through 5 July 2023
ER -