Polyketides from the endophytic fungus Cladosporium sp. isolated from the mangrove plant excoecaria agallocha

Liping Wang; Xiuli Han; Guoliang Zhu; Yi Wang; Arthit Chairoungdua; Pawinee Piyachaturawat; Weiming Zhu

doi:10.3389/fchem.2018.00344

Polyketides from the endophytic fungus Cladosporium sp. isolated from the mangrove plant excoecaria agallocha

Liping Wang, Xiuli Han, Guoliang Zhu, Yi Wang, Arthit Chairoungdua, Pawinee Piyachaturawat, Weiming Zhu

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Five new polyketides (2-6) and ten known compounds (1 and 7-15) were obtained from the fermentation products of the endophytic fungus Cladosporium sp. OUCMDZ-302 with the mangrove plant, Excoecaria agallocha (Euphorbiaceae). The new structures of 2-6 were established on the basis of ECD, specific rotation and spectroscopic data as well as the chemical calculation. Compound 7 showed cytotoxicity against H1975 cell line with an IC₅₀ value of 10.0 μM. Compounds 4 and 8-10 showed radical scavenging activity against DPPH with the IC₅₀ values of 2.65, 0.24, 5.66, and 6.67 μM, respectively. In addition, the absolute configuration of compound 1 was solidly determined by X-ray and sugar analysis of the acidic hydrolysates for the first time as well as those of compounds 8-10 in this paper.

Original language	English
Article number	344
Journal	Frontiers in Chemistry
Volume	6
Issue number	AUG
DOIs	https://doi.org/10.3389/fchem.2018.00344
Publication status	Published - 1 Aug 2018
Externally published	Yes

Keywords

Anti-oxidation
Cadosporium sp.
Excoecaria agallocha
Mangrove fungus
Polyketides

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10.3389/fchem.2018.00344

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title = "Polyketides from the endophytic fungus Cladosporium sp. isolated from the mangrove plant excoecaria agallocha",

abstract = "Five new polyketides (2-6) and ten known compounds (1 and 7-15) were obtained from the fermentation products of the endophytic fungus Cladosporium sp. OUCMDZ-302 with the mangrove plant, Excoecaria agallocha (Euphorbiaceae). The new structures of 2-6 were established on the basis of ECD, specific rotation and spectroscopic data as well as the chemical calculation. Compound 7 showed cytotoxicity against H1975 cell line with an IC50 value of 10.0 μM. Compounds 4 and 8-10 showed radical scavenging activity against DPPH with the IC50 values of 2.65, 0.24, 5.66, and 6.67 μM, respectively. In addition, the absolute configuration of compound 1 was solidly determined by X-ray and sugar analysis of the acidic hydrolysates for the first time as well as those of compounds 8-10 in this paper.",

keywords = "Anti-oxidation, Cadosporium sp., Excoecaria agallocha, Mangrove fungus, Polyketides",

author = "Liping Wang and Xiuli Han and Guoliang Zhu and Yi Wang and Arthit Chairoungdua and Pawinee Piyachaturawat and Weiming Zhu",

note = "Publisher Copyright: {\textcopyright} 2018 Wang, Han, Zhu, Wang, Chairoungdua, Piyachaturawat and Zhu.",

year = "2018",

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doi = "10.3389/fchem.2018.00344",

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AU - Wang, Liping

AU - Han, Xiuli

AU - Zhu, Guoliang

AU - Wang, Yi

AU - Chairoungdua, Arthit

AU - Piyachaturawat, Pawinee

AU - Zhu, Weiming

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Five new polyketides (2-6) and ten known compounds (1 and 7-15) were obtained from the fermentation products of the endophytic fungus Cladosporium sp. OUCMDZ-302 with the mangrove plant, Excoecaria agallocha (Euphorbiaceae). The new structures of 2-6 were established on the basis of ECD, specific rotation and spectroscopic data as well as the chemical calculation. Compound 7 showed cytotoxicity against H1975 cell line with an IC50 value of 10.0 μM. Compounds 4 and 8-10 showed radical scavenging activity against DPPH with the IC50 values of 2.65, 0.24, 5.66, and 6.67 μM, respectively. In addition, the absolute configuration of compound 1 was solidly determined by X-ray and sugar analysis of the acidic hydrolysates for the first time as well as those of compounds 8-10 in this paper.

AB - Five new polyketides (2-6) and ten known compounds (1 and 7-15) were obtained from the fermentation products of the endophytic fungus Cladosporium sp. OUCMDZ-302 with the mangrove plant, Excoecaria agallocha (Euphorbiaceae). The new structures of 2-6 were established on the basis of ECD, specific rotation and spectroscopic data as well as the chemical calculation. Compound 7 showed cytotoxicity against H1975 cell line with an IC50 value of 10.0 μM. Compounds 4 and 8-10 showed radical scavenging activity against DPPH with the IC50 values of 2.65, 0.24, 5.66, and 6.67 μM, respectively. In addition, the absolute configuration of compound 1 was solidly determined by X-ray and sugar analysis of the acidic hydrolysates for the first time as well as those of compounds 8-10 in this paper.

KW - Anti-oxidation

KW - Cadosporium sp.

KW - Excoecaria agallocha

KW - Mangrove fungus

KW - Polyketides

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DO - 10.3389/fchem.2018.00344

M3 - Article

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VL - 6

JO - Frontiers in Chemistry

JF - Frontiers in Chemistry

IS - AUG

M1 - 344

ER -

Polyketides from the endophytic fungus Cladosporium sp. isolated from the mangrove plant excoecaria agallocha

Abstract

Keywords

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