@inproceedings{c9a9c5fa6ab64672a52db830baba044b,
title = "Preparation of biocompatible PVA hydrogels as wound dressings by gamma irradiation",
abstract = "Hydrogels have emerged as a new class of materials that are capable of providing appropriate moist environment for wound healing. In this report, gamma irradiation was utilized to prepare flexible, self-Adhesive, and biocompatible hydrogel sheets from polyvinyl alcohol (PVA) as wound dressings. The PVA concentrations ranged from 6-10 % (w/v) and gamma doses from 10-80 kGy were first varied to optimize the formation of crosslinked, three-dimensional structure of hydrogels. Based on swelling behavior, the 10% (w/v) PVA solution crosslinked at the dose of 40 kGy was selected to fabricate prototypic hydrogel sheets that could conform over skin contour. The extraction-based MTT assay showed that the hydrogel sheets were cytocompatible with L929 cells. When applied on full-Thickness defects in rat model, the hydrogel sheets could facilitate re-epithelization to complete wound closure. These results demonstrate that our PVA hydrogel sheets developed by gamma irradiation can serve as a suitable candidate for wound dressings.",
keywords = "Wound dressing, cytocompatible, gamma irradiation, polyvinyl alcohol, wound healing",
author = "R. Chiangnoon and P. Karawak and J. Eamsiri and N. Thamrongsiripak and P. Uttayarat and W. Angkhasirisap and S. Ampawong",
note = "Publisher Copyright: {\textcopyright} 2022 IEEE.; 14th Biomedical Engineering International Conference, BMEiCON 2022 ; Conference date: 10-11-2022 Through 13-11-2022",
year = "2022",
doi = "10.1109/BMEiCON56653.2022.10012079",
language = "English",
series = "BMEiCON 2022 - 14th Biomedical Engineering International Conference",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "BMEiCON 2022 - 14th Biomedical Engineering International Conference",
}