Preparation of biocompatible PVA hydrogels as wound dressings by gamma irradiation

R. Chiangnoon, P. Karawak, J. Eamsiri, N. Thamrongsiripak, P. Uttayarat, W. Angkhasirisap, S. Ampawong

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Hydrogels have emerged as a new class of materials that are capable of providing appropriate moist environment for wound healing. In this report, gamma irradiation was utilized to prepare flexible, self-Adhesive, and biocompatible hydrogel sheets from polyvinyl alcohol (PVA) as wound dressings. The PVA concentrations ranged from 6-10 % (w/v) and gamma doses from 10-80 kGy were first varied to optimize the formation of crosslinked, three-dimensional structure of hydrogels. Based on swelling behavior, the 10% (w/v) PVA solution crosslinked at the dose of 40 kGy was selected to fabricate prototypic hydrogel sheets that could conform over skin contour. The extraction-based MTT assay showed that the hydrogel sheets were cytocompatible with L929 cells. When applied on full-Thickness defects in rat model, the hydrogel sheets could facilitate re-epithelization to complete wound closure. These results demonstrate that our PVA hydrogel sheets developed by gamma irradiation can serve as a suitable candidate for wound dressings.

Original languageEnglish
Title of host publicationBMEiCON 2022 - 14th Biomedical Engineering International Conference
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781665489034
DOIs
Publication statusPublished - 2022
Event14th Biomedical Engineering International Conference, BMEiCON 2022 - Virtual, Online, Thailand
Duration: 10 Nov 202213 Nov 2022

Publication series

NameBMEiCON 2022 - 14th Biomedical Engineering International Conference

Conference

Conference14th Biomedical Engineering International Conference, BMEiCON 2022
Country/TerritoryThailand
CityVirtual, Online
Period10/11/2213/11/22

Keywords

  • Wound dressing
  • cytocompatible
  • gamma irradiation
  • polyvinyl alcohol
  • wound healing

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