Renal biomarkers in cats: A review of the current status in chronic kidney disease

Thirawut Kongtasai, Dominique Paepe, Evelyne Meyer, Femke Mortier, Sofie Marynissen, Lisa Stammeleer, Pieter Defauw, Sylvie Daminet

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

Serum creatinine concentration, the classical biomarker of chronic kidney disease (CKD) in cats, has important limitations that decrease its value as a biomarker of early CKD. Recently, serum symmetric dimethylarginine concentration was introduced as a novel glomerular filtration rate biomarker for the early detection of CKD in cats. However, data on its specificity are still limited. The limitations of conventional biomarkers and the desire for early therapeutic intervention in cats with CKD to improve outcomes have prompted the discovery and validation of novel renal biomarkers to detect glomerular or tubular dysfunction. Changes in the serum or urinary concentrations of these biomarkers may indicate early kidney damage or predict the progression of kidney before changes in conventional biomarkers are detectable. This review summarizes current knowledge on renal biomarkers in CKD in cats, a field that has progressed substantially over the last 5 years.

Original languageEnglish
Pages (from-to)379-396
Number of pages18
JournalJournal of Veterinary Internal Medicine
Volume36
Issue number2
DOIs
Publication statusPublished - Mar 2022

Keywords

  • feline
  • fibroblast growth factor-23
  • kidney injury molecule-1
  • liver-type fatty acid-binding protein
  • neutrophil gelatinase-associated lipocalin
  • transforming growth factor-β1

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