TY - JOUR
T1 - Renal biomarkers in cats
T2 - A review of the current status in chronic kidney disease
AU - Kongtasai, Thirawut
AU - Paepe, Dominique
AU - Meyer, Evelyne
AU - Mortier, Femke
AU - Marynissen, Sofie
AU - Stammeleer, Lisa
AU - Defauw, Pieter
AU - Daminet, Sylvie
N1 - Publisher Copyright:
© 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
PY - 2022/3
Y1 - 2022/3
N2 - Serum creatinine concentration, the classical biomarker of chronic kidney disease (CKD) in cats, has important limitations that decrease its value as a biomarker of early CKD. Recently, serum symmetric dimethylarginine concentration was introduced as a novel glomerular filtration rate biomarker for the early detection of CKD in cats. However, data on its specificity are still limited. The limitations of conventional biomarkers and the desire for early therapeutic intervention in cats with CKD to improve outcomes have prompted the discovery and validation of novel renal biomarkers to detect glomerular or tubular dysfunction. Changes in the serum or urinary concentrations of these biomarkers may indicate early kidney damage or predict the progression of kidney before changes in conventional biomarkers are detectable. This review summarizes current knowledge on renal biomarkers in CKD in cats, a field that has progressed substantially over the last 5 years.
AB - Serum creatinine concentration, the classical biomarker of chronic kidney disease (CKD) in cats, has important limitations that decrease its value as a biomarker of early CKD. Recently, serum symmetric dimethylarginine concentration was introduced as a novel glomerular filtration rate biomarker for the early detection of CKD in cats. However, data on its specificity are still limited. The limitations of conventional biomarkers and the desire for early therapeutic intervention in cats with CKD to improve outcomes have prompted the discovery and validation of novel renal biomarkers to detect glomerular or tubular dysfunction. Changes in the serum or urinary concentrations of these biomarkers may indicate early kidney damage or predict the progression of kidney before changes in conventional biomarkers are detectable. This review summarizes current knowledge on renal biomarkers in CKD in cats, a field that has progressed substantially over the last 5 years.
KW - feline
KW - fibroblast growth factor-23
KW - kidney injury molecule-1
KW - liver-type fatty acid-binding protein
KW - neutrophil gelatinase-associated lipocalin
KW - transforming growth factor-β1
UR - http://www.scopus.com/inward/record.url?scp=85125246364&partnerID=8YFLogxK
U2 - 10.1111/jvim.16377
DO - 10.1111/jvim.16377
M3 - Review article
C2 - 35218249
AN - SCOPUS:85125246364
SN - 0891-6640
VL - 36
SP - 379
EP - 396
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
IS - 2
ER -