TY - JOUR
T1 - Revisiting Fruit Allergy
T2 - Prevalence across the Globe, Diagnosis, and Current Management
AU - Krikeerati, Thanachit
AU - Rodsaward, Pongsawat
AU - Nawiboonwong, Jutamard
AU - Pinyopornpanish, Kanokkarn
AU - Phusawang, Songwut
AU - Sompornrattanaphan, Mongkhon
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/11
Y1 - 2023/11
N2 - Fruit allergies manifest with a diverse array of clinical presentations, ranging from localized contact allergies and oral allergy syndrome to the potential for severe systemic reactions including anaphylaxis. The scope of population-level prevalence studies remains limited, largely derived from single-center or hospital-based investigations. In this comprehensive review, we conducted a systematic literature search spanning the years 2009 to 2023, with full acknowledgment of potential analytical biases, to provide a global overview of fruit allergy prevalence. The primary mechanistic underpinning of fruit allergies stems from cross-reactivity between aeroallergens and food allergens, a consequence of structurally similar epitopes—a phenomenon recognized as pollen food allergy syndrome (PFAS). In the era of molecular allergology, numerous studies have dissected allergen components with substantial clinical relevance. Within this review, we explore important allergenic molecules found in plant-based foods, scrutinize pertinent cross-reactivity patterns, and offer insights into management recommendations. Additionally, we compare guideline recommendations to enhance clinical understanding and inform decision making.
AB - Fruit allergies manifest with a diverse array of clinical presentations, ranging from localized contact allergies and oral allergy syndrome to the potential for severe systemic reactions including anaphylaxis. The scope of population-level prevalence studies remains limited, largely derived from single-center or hospital-based investigations. In this comprehensive review, we conducted a systematic literature search spanning the years 2009 to 2023, with full acknowledgment of potential analytical biases, to provide a global overview of fruit allergy prevalence. The primary mechanistic underpinning of fruit allergies stems from cross-reactivity between aeroallergens and food allergens, a consequence of structurally similar epitopes—a phenomenon recognized as pollen food allergy syndrome (PFAS). In the era of molecular allergology, numerous studies have dissected allergen components with substantial clinical relevance. Within this review, we explore important allergenic molecules found in plant-based foods, scrutinize pertinent cross-reactivity patterns, and offer insights into management recommendations. Additionally, we compare guideline recommendations to enhance clinical understanding and inform decision making.
KW - IgE
KW - anaphylaxis
KW - food allergy
KW - food safety
KW - food-dependent exercise-induced anaphylaxis
KW - fruit allergy
KW - fruit hypersensitivity
KW - gluten
KW - oral food challenge
KW - plant food allergies
UR - http://www.scopus.com/inward/record.url?scp=85178376213&partnerID=8YFLogxK
U2 - 10.3390/foods12224083
DO - 10.3390/foods12224083
M3 - Review article
AN - SCOPUS:85178376213
VL - 12
JO - Foods
JF - Foods
IS - 22
M1 - 4083
ER -