Revisiting Fruit Allergy: Prevalence across the Globe, Diagnosis, and Current Management

Thanachit Krikeerati, Pongsawat Rodsaward, Jutamard Nawiboonwong, Kanokkarn Pinyopornpanish, Songwut Phusawang, Mongkhon Sompornrattanaphan

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

Fruit allergies manifest with a diverse array of clinical presentations, ranging from localized contact allergies and oral allergy syndrome to the potential for severe systemic reactions including anaphylaxis. The scope of population-level prevalence studies remains limited, largely derived from single-center or hospital-based investigations. In this comprehensive review, we conducted a systematic literature search spanning the years 2009 to 2023, with full acknowledgment of potential analytical biases, to provide a global overview of fruit allergy prevalence. The primary mechanistic underpinning of fruit allergies stems from cross-reactivity between aeroallergens and food allergens, a consequence of structurally similar epitopes—a phenomenon recognized as pollen food allergy syndrome (PFAS). In the era of molecular allergology, numerous studies have dissected allergen components with substantial clinical relevance. Within this review, we explore important allergenic molecules found in plant-based foods, scrutinize pertinent cross-reactivity patterns, and offer insights into management recommendations. Additionally, we compare guideline recommendations to enhance clinical understanding and inform decision making.

Original languageEnglish
Article number4083
JournalFoods
Volume12
Issue number22
DOIs
Publication statusPublished - Nov 2023

Keywords

  • IgE
  • anaphylaxis
  • food allergy
  • food safety
  • food-dependent exercise-induced anaphylaxis
  • fruit allergy
  • fruit hypersensitivity
  • gluten
  • oral food challenge
  • plant food allergies

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