Streptozotocin induces alpha-2u globulin nephropathy in male rats during diabetic kidney disease

Kanchana Kengkoom, Wannee Angkhasirisap, Tapanee Kanjanapruthipong, Rongdej Tungtrakanpoung, Khwanchanok Tuentam, Naphatson Phansom, Sumate Ampawong

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background: Alpha-2u globulin nephropathy mainly shows toxicological pathology only in male rats induced by certain chemicals and drugs, such as levamisole (antiparasitic and anticancer drugs). Streptozotocin (STZ) is also an anticancer-antibiotic agent that has been used for decades to induce a diabetic kidney disease model in rodents. The purpose of this study is to determine if STZ causes alpha-2u globulin nephropathy in male rats during an advanced stage of diabetic kidney disease. Alpha-2u globulin nephropathy, water absorption and filtration capacities (via aquaporin [AQP]-1, − 2, − 4 and − 5) and mitochondrial function (through haloacid dehalogenase-like hydrolase domain-containing protein [HDHD]-3 and NADH-ubiquinone oxidoreductase 75 kDa subunit [NDUFS]-1 proteins) were examined in STZ-induced diabetic Wistar rat model. Results: More than 80% of severe clinical illness rats induced by STZ injection simultaneously exhibited alpha-2u globulin nephropathy with mitochondrial degeneration and filtration apparatus especially pedicels impairment. They also showed significantly upregulated AQP-1, − 2, − 4 and − 5, HDHD-3 and NDUFS-1 compared with those of the rats without alpha-2u globulin nephropathy. Conclusions: STZ-induced alpha-2u globulin nephropathy during diabetic kidney disease in association with deterioration of pedicels, renal tubular damage with adaptation and mitochondrial driven apoptosis.

Original languageEnglish
Article number105
JournalBMC Veterinary Research
Volume17
Issue number1
DOIs
Publication statusPublished - Dec 2021

Keywords

  • Alpha-2u globulin
  • Diabetic kidney disease
  • Histopathology
  • Nephropathy
  • Streptozotocin

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