TY - GEN
T1 - Synthesis, processing and testing of A poly(DL-lactide-CO-ε- caprolactone) resorbable electrospun membrane for guided tissue regeneration
AU - Piyakunakorn, P.
AU - Khumraksa, B.
AU - Thapsukhon, B.
AU - Rassameemasmaung, S.
AU - Molloy, R.
AU - Suchiva, K.
AU - Punyodom, W.
PY - 2012
Y1 - 2012
N2 - The aim of this study was to fabricate 75:25 poly(DL-lactide-co-ε- caprolactone), poly(DLL-co-CL) membranes for used in guided tissue regeneration (GTR). The copolymer was synthesized by ring-opening polymerization (ROP) in bulk. The 3-dimensional fiber networks with built-in microporosity membranes were prepared by electrospinning. The pore size was varied between 5-30 μm and the porosity of membrane was 69%. After immersing in phosphate buffered saline (PBS), the membranes were degradable with time, as indicated by molecular weight loss, mass weight loss, reduction of pH of the media and changes in the surface topography and shape of the membranes. However, the in vitro hydrolytic degradation of the membranes was too fast for use as periodontal GTR. The membranes maintained their original shape for the first 4 weeks and the porous structure disappeared within 2 weeks. Results from agar diffusion test suggest the membranes to be non-cytotoxic. In conclusion, the electrospun membrane was non-cytotoxic but the degradation rate was too fast to be used as GTR membrane in periodontal treatment.
AB - The aim of this study was to fabricate 75:25 poly(DL-lactide-co-ε- caprolactone), poly(DLL-co-CL) membranes for used in guided tissue regeneration (GTR). The copolymer was synthesized by ring-opening polymerization (ROP) in bulk. The 3-dimensional fiber networks with built-in microporosity membranes were prepared by electrospinning. The pore size was varied between 5-30 μm and the porosity of membrane was 69%. After immersing in phosphate buffered saline (PBS), the membranes were degradable with time, as indicated by molecular weight loss, mass weight loss, reduction of pH of the media and changes in the surface topography and shape of the membranes. However, the in vitro hydrolytic degradation of the membranes was too fast for use as periodontal GTR. The membranes maintained their original shape for the first 4 weeks and the porous structure disappeared within 2 weeks. Results from agar diffusion test suggest the membranes to be non-cytotoxic. In conclusion, the electrospun membrane was non-cytotoxic but the degradation rate was too fast to be used as GTR membrane in periodontal treatment.
KW - Electrospinning
KW - Guided tissue regeneration
KW - In vitro evaluation
KW - Resorbable membrane
UR - http://www.scopus.com/inward/record.url?scp=84860795377&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/AMR.506.110
DO - 10.4028/www.scientific.net/AMR.506.110
M3 - Conference contribution
AN - SCOPUS:84860795377
SN - 9783037854068
T3 - Advanced Materials Research
SP - 110
EP - 113
BT - Biomaterials and Applications
T2 - Chiang Mai International Conference on Biomaterials and Applications, CMICBA 2011
Y2 - 9 August 2011 through 10 August 2011
ER -