TY - JOUR
T1 - The influence of leukocyte-platelet-rich plasma on accelerated orthodontic tooth movement in rabbits
AU - Nakornnoi, Theerasak
AU - Leethanakul, Chidchanok
AU - Samruajbenjakun, Bancha
N1 - Publisher Copyright:
© 2019 The Korean Association of Orthodontists.
PY - 2019/11
Y1 - 2019/11
N2 - Objective: To determine the effects of a local injection of leukocyte-platelet-rich plasma (L-PRP) on orthodontic tooth movement in rabbits. Methods: Twenty-three male New Zealand white rabbits were included in a split-mouth design. Tooth movement with a 100-g nickel-titanium closed-coil spring was performed on the maxillary first premolars. L-PRP was injected submucosally at the buccal and lingual areas of the first premolar in one random side of the maxilla and the other side served as the control and received normal saline. The amount of tooth movement was assessed on three-dimensional digital models on days 0, 3, 7, 14, 21, and 28. Histological findings and osteoclast numbers were examined on day 0 as the baseline and on days 7, 14, and 28. Results: The L-PRP group showed significantly greater cumulative tooth movement at all observed periods. However, a significantly higher rate of tooth movement was observed only on days 0–7 and 7–14. The osteoclast numbers were significantly increased in the L-PRP group on days 7 and 14. Conclusions: Local injection of L-PRP resulted in a transient increase in the rate of tooth movement and higher osteoclast numbers.
AB - Objective: To determine the effects of a local injection of leukocyte-platelet-rich plasma (L-PRP) on orthodontic tooth movement in rabbits. Methods: Twenty-three male New Zealand white rabbits were included in a split-mouth design. Tooth movement with a 100-g nickel-titanium closed-coil spring was performed on the maxillary first premolars. L-PRP was injected submucosally at the buccal and lingual areas of the first premolar in one random side of the maxilla and the other side served as the control and received normal saline. The amount of tooth movement was assessed on three-dimensional digital models on days 0, 3, 7, 14, 21, and 28. Histological findings and osteoclast numbers were examined on day 0 as the baseline and on days 7, 14, and 28. Results: The L-PRP group showed significantly greater cumulative tooth movement at all observed periods. However, a significantly higher rate of tooth movement was observed only on days 0–7 and 7–14. The osteoclast numbers were significantly increased in the L-PRP group on days 7 and 14. Conclusions: Local injection of L-PRP resulted in a transient increase in the rate of tooth movement and higher osteoclast numbers.
KW - Leukocyte-platelet-rich plasma
KW - Orthodontics
KW - Tooth movement
UR - http://www.scopus.com/inward/record.url?scp=85075719241&partnerID=8YFLogxK
U2 - 10.4041/kjod.2019.49.6.372
DO - 10.4041/kjod.2019.49.6.372
M3 - Article
AN - SCOPUS:85075719241
SN - 2234-7518
VL - 49
SP - 372
EP - 380
JO - Korean Journal of Orthodontics
JF - Korean Journal of Orthodontics
IS - 6
ER -