The study of tryptophol containing emulgel on fungal reduction and skin irritation

Thitinan Kitisin, Watcharamat Muangkaew, Natthawut Thitipramote, Arnon Pudgerd, Passanesh Sukphopetch

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Tryptophol (TOH), a fungal quorum-sensing molecule, that possesses anti-fungal activities for controlling the growth of human pathogenic fungi. In the present study, we developed TOH-containing emulgel formulations and examined the antifungal activities and potential use as topical treatments on the skin. The results showed that TOH-containing emulgel at 1000 μM has excellent physical characteristics as homogenous, stability, and inhibits the growth of 30 species of human pathogenic fungi in vitro. TOH-containing emulgel did not cause skin irritation in mouse model of irritation and in healthy human volunteers. Moreover, an increase in skin hydration and a decrease in trans-epidermal water loss (TEWL) were observed after TOH-containing emulgel treatment on human skin. Our findings indicated that TOH-containing emulgel can be utilize as an antifungal agent for topical treatment against fungal infections on the skin.

Original languageEnglish
Article number18881
JournalScientific Reports
Volume13
Issue number1
DOIs
Publication statusPublished - Dec 2023

Fingerprint

Dive into the research topics of 'The study of tryptophol containing emulgel on fungal reduction and skin irritation'. Together they form a unique fingerprint.

Cite this